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2-amino-4-phosphonobutyric Acid: A New Pharmacological Tool for Retina Research

M M Slaughter, R F Miller

Science. 1981 Jan 9;211(4478):182-5.

PMID: 6255566

Abstract:

Information processing in the vertebrate retina occurs in two separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP20263074 (±)-2-Amino-4-phosphonobutyric acid (±)-2-Amino-4-phosphonobutyric acid 20263-07-4 Price
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