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2-Aminoethyl Diphenylborinate (2-APB) Analogues: Regulation of Ca2+ Signaling

2-Aminoethyl Diphenylborinate (2-APB) Analogues: Regulation of Ca2+ Signaling

Shoichiro Ozaki, Akinobu Z Suzuki, Peter O Bauer, Etsuko Ebisui, Katsuhiko Mikoshiba

Biochem Biophys Res Commun. 2013 Nov 15;441(2):286-90.

PMID: 24036266

Abstract:

In order to obtain compounds with modified 2-APB activities, we synthesized number of 2-APB analogues and analyzed their inhibitory activities for SOCE. The IC50 of 2-APB for SOCE inhibition is 3 μM while IC50 of some of our 2-APB analogues range 0.1-10 μM. The adducts of amino acids with diphenyl borinic acid have strong inhibitory activities. By using these compounds, we will be able to regulate intracellular Ca(2+) concentration and consequent cellular processes more efficiently than with 2-APB.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP524958	2-Aminoethyl diphenylborinate		524-95-8	Price

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