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2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

B Pajak, E Siwiak, M Sołtyka, A Priebe, R Zieliński, I Fokt, M Ziemniak, A Jaśkiewicz, R Borowski, T Domoradzki, W Priebe

Int J Mol Sci. 2019 Dec 29;21(1):234.

PMID: 31905745

Abstract:

The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death. In addition to glycolysis inhibition, other molecular processes are also affected by 2-DG. Attempts to improve 2-DG's drug-like properties, its role as a potential adjuvant for other chemotherapeutics, and novel 2-DG analogs as promising new anticancer agents are discussed in this review.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP154176-A	2-Deoxy-D-glucose		154-17-6	Price

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