0

2-Hydroxyindoline-3-triethylammonium Bromide: A Reagent for Formal C3-Electrophilic Reactions of Indoles

Takumi Abe, Takuro Suzuki, Masahiro Anada, Shigeki Matsunaga, Koji Yamada

Org Lett. 2017 Aug 18;19(16):4275-4278.

PMID: 28762744

Abstract:

A novel indole-2,3-epoxide equivalent, 2-hydroxyindoline-3-triethylammonium bromide, was found to be a convenient reagent for formal C3-electrophilic reactions of indoles with various nucleophiles. By taking advantage of the nucleophilic character of the oxygen of the 2-hydroxyindoline, the interrupted retro-Claisen and interrupted Feist-Bénary reactions with 1,3-dicarbonyl compounds were efficiently achieved.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP134640850 2,3-Dimethylphenylmagnesium bromide 2,3-Dimethylphenylmagnesium bromide 134640-85-0 Price
qrcode