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2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) Selectively Antagonises N-methyl-aspartate (NMA)

2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) Selectively Antagonises N-methyl-aspartate (NMA)

J C Blake, S N Davies, J Church, D Martin, D Lodge

Pharmacol Biochem Behav. 1986 Jan;24(1):23-5.

PMID: 3511477

Abstract:

Using electrophoretic application to rat central neurones in vivo, and bath application to frog spinal cord in vitro, 2-methyl-3,3-diphenyl-3-propanolamine was found to be a selective antagonist of N-methyl-DL-aspartate, but not of quisqualate or kainate. In this respect the (-) isomer proved to be about three times more potent than the (+) in both preparations.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP156876-B	Propanolamine		156-87-6	Price

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