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2-substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-one as a Structurally New NK1 Antagonist

2-substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-one as a Structurally New NK1 Antagonist

Shigeki Seto, Asao Tanioka, Makoto Ikeda, Shigeru Izawa

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1485-8.

PMID: 15713412

Abstract:

The structurally novel pyrimido[4,5-b][1,5]oxazocine derivative 3, a hybrid compound of pyrido[4,3-b]- and [2,3-b]-1,5-oxazocine (1 and 2, respectively), was designed and synthesized. We examined the atropisomeric property and the NK1 antagonist activity of 3. Compound 3 was found to possess both a feature of 1, free rotation about the biaryl bond, and a feature of 2, potent in vivo activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1173018795	1,7-Dimethylxanthine-2,4,5,6-13C4-1,3,9-15N3		1173018-79-5	Price

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