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24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

Min-Yu Sun, Andrew J Linsenbardt, Christine M Emnett, Lawrence N Eisenman, Yukitoshi Izumi, Charles F Zorumski, Steve Mennerick

Neuroscientist. 2016 Apr;22(2):132-44.

PMID: 25628343

Abstract:

The major cholesterol metabolite in brain, 24(S)-hydroxycholesterol (24S-HC), serves as a vehicle for cholesterol removal. Its effects on neuronal function, however, have only recently begun to be investigated. Here, we review that nascent work. Our own studies have demonstrated that 24S-HC has potent positive modulatory effects on N-methyl-d-aspartate (NMDA) receptor (NMDAR) function. This could have implications not only for brain plasticity but also for pathological NMDAR overuse. Other work has demonstrated effects of 24S-HC on neuronal survival and as a possible biomarker of neurodegenerative disease. Depending on circumstances, both upregulation/mimicry of 24S-HC signaling and down-regulation/antagonism may have therapeutic potential. We are interested in the possibility that synthetic analogues of 24S-HC with positive effects at NMDARs may hold neurotherapeutic promise, given the role of NMDA receptor hypofunction in certain neuropsychiatric disorders.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP474737	24(S)-Hydroxycholesterol		474-73-7	Price

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