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3,4,5-Trimethoxycinnamic Acid, One of the Constituents of Polygalae Radix Exerts Anti-Seizure Effects by Modulating GABAAergic Systems in Mice

3,4,5-Trimethoxycinnamic Acid, One of the Constituents of Polygalae Radix Exerts Anti-Seizure Effects by Modulating GABAAergic Systems in Mice

Chang-Yuan Chen, Xu-Dong Wei, Chang-Rui Chen

J Pharmacol Sci. 2016 May;131(1):1-5.

PMID: 26260747

Abstract:

Polygalae Radix is an important medicinal plant that is widely used in most of Africa. 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix. Until now, the mechanisms involved in the anti-seizure property of TMCA are still unclear. We examined the anti-seizure effect of TMCA. TMCA administered at doses of 5, 10 and 20 mg/kg and evaluated anti-seizure effects by maximal electroshock (MES) and pentylenetetrazol (PTZ) models in mice. TMCA administered at doses of 10 and 20 mg/kg significantly reduced the incidence of MES-induced tonic hindlimb extension (THE). TMCA significantly delayed the onset of myoclonic jerks (MJ), and decreased the seizure severity and mortality compared with the vehicle-treated animals in PTZ seizure model. TMCA 10 and 20 mg/kg treated groups also did not determined generalized clonic seizures (GCS). Pretreatment with a GABAA/benzodiazepine (BZ) receptor antagonist flumazenil blocked the anti-seizure effects of TMCA. These data support the further investigation of TMCA as a GABAA/BZ receptor agonist for anti-seizure therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP90506	3,4,5-Trimethoxycinnamic acid		90-50-6	Price

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