Home
Resources
Publications
3,4,5-Trimethoxycinnamin Acid Ameliorates Restraint Stress-Induced Anxiety and Depression

3,4,5-Trimethoxycinnamin Acid Ameliorates Restraint Stress-Induced Anxiety and Depression

Yea-Hyun Leem, Seikwan Oh

Neurosci Lett. 2015 Jan 12;585:54-9.

PMID: 25445378

Abstract:

The present study investigated whether 3,4,5-trimethoxycinnamic acid (TMCA) treatment ameliorated restraint stress-provoked anxiety- and depression-like behaviors in mice. Fourteen consecutive days of restraint stress produced anxiety- and depression-like behaviors, including reduced time and frequency in the open arms of the elevated plus maze (EPM), as well as enhanced immobility times in the forced swim test (FST). However, TMCA (50 mg/kg) treatment ameliorated this effect; mice showed increased time and frequency of visits in the open arms of the EPM and showed reduced immobility in the FST. In parallel with the behavioral data, long-lasting stimulation of ΔFosB in the nucleus accumbens shell subregion was exhibited in response to TMCA. Furthermore, a reduction in expression of SC1, a target of ΔFosB, in the nucleus accumbens of mice subjected to restraint stress was significantly reversed by TMCA (50 mg/kg) treatment. Collectively, these results suggest that TMCA treatment might provide a therapeutic strategy for treatment of anxiety and depression.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP90506	3,4,5-Trimethoxycinnamic acid		90-50-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: