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3,4-Dichloroisocoumarin, a Serine Protease Inhibitor, Inactivates Glycogen Phosphorylase B

3,4-Dichloroisocoumarin, a Serine Protease Inhibitor, Inactivates Glycogen Phosphorylase B

N M Rusbridge, R J Beynon

FEBS Lett. 1990 Jul 30;268(1):133-6.

PMID: 2384149

Abstract:

3,4-Dichloroisocoumarin (3,4-DCI) is a highly reactive, mechanism-based inhibitor of serine proteases. We show here that glycogen phosphorylase b is also inactivated by this inhibitor, in a mechanism that parallels the inactivation of serine proteases, but involving multiple sites of covalent modification. Such a process may compromise studies in which 3,4-DCI is used to arrest proteolysis of a second native protein which may itself be modified.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51050590	3,4-Dichloroisocoumarin		51050-59-0	Price

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