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3,4-Dihydroxybenzaldehyde Derived From Prunus Mume Seed Inhibits Oxidative Stress and Enhances Estradiol Secretion in Human Ovarian Granulosa Tumor Cells

3,4-Dihydroxybenzaldehyde Derived From Prunus Mume Seed Inhibits Oxidative Stress and Enhances Estradiol Secretion in Human Ovarian Granulosa Tumor Cells

Ryohei Kono, Sachiko Nomura, Yoshiharu Okuno, Misa Nakamura, Akihiro Maeno, Tomoko Kagiya, Akihiko Tokuda, Ken-Ichi Inada, Akira Matsuno, Tomoko Utsunomiya, Hirotoshi Utsunomiya

Acta Histochem Cytochem. 2014 Jun 28;47(3):103-12.

PMID: 25320407

Abstract:

Granulosa cells form ovarian follicles and play important roles in the growth and maturation of oocytes. The protection of granulosa cells from cellular injury caused by oxidative stress is an effective therapy for female infertility. We here investigated an effective bioactive compound derived from Prunus mume seed extract that protects granulosa cells from hydrogen peroxide (H2O2)-induced apoptosis. We detected the bioactive compound, 3,4-dihydroxybenzaldehyde (3,4-DHBA), via bioactivity-guided isolation and found that it inhibited the H2O2-induced apoptosis of granulosa cells. We also showed that 3,4-DHBA promoted estradiol secretion in granulosa cells and enhanced the mRNA expression levels of steroidogenic factor 1, a promoter of key steroidogenic enzymes. These results suggest that P. mume seed extract may have clinical potential for the prevention and treatment of female infertility.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP139855	3,4-Dihydroxybenzaldehyde		139-85-5	Price

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