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3-acetyl-11-keto-beta-boswellic Acid Decreases the Malignancy of Taxol Resistant Human Ovarian Cancer by Inhibiting Multidrug Resistance (MDR) Proteins Function

3-acetyl-11-keto-beta-boswellic Acid Decreases the Malignancy of Taxol Resistant Human Ovarian Cancer by Inhibiting Multidrug Resistance (MDR) Proteins Function

Lu Jin, Wang Yingchun, Shi Zhujun, Wu Yinan, Wu Dongchen, Yu Hui, Yu Xi, Zhao Wanzhou, Zhu Buluan, Wang Jinhua

Biomed Pharmacother. 2019 Aug;116:108992.

PMID: 31129513

Abstract:

Objective:
Recurrence of ovarian cancer is mainly due to multidrug resistance (MDR). 3-acetyl-11-keto-beta-boswellic acid (AKBA) could reverse the multidrug resistance in human ileocecal adenocarcinoma cells, but whether AKBA could modulate acquired MDR in ovarian cancer needs to be elucidated.
Methods:
The current study examined the effect of AKBA on ovarian cancer MDR using a Taxol resistant human ovarian cancer cell line A2780/Taxol. Cell proliferation, migration and invasion, the intracellular accumulation of Rhodamine 123 and expression of MDR proteins were studiedin vitro. Furthermore, the effect of AKBA on oncogenicity of A2780/Taxol cells in nude mice xenograft model was studied.
Results:
The results showed that apart from its cytostatic and apoptosis-induction effect, AKBA could restrain A2780/Taxol cell migration and invasion. In addition, AKBA improved the sensitivity of A2780/Taxol cells to Taxol apparently, and the reversal of MDR by AKBA was evident by increasing intracellular Rhodamine 123 in cells. Furthermore, the anti-cancer potential of AKBA was evidenced as that AKBA treatment significantly slowed tumor growth and decreased the expression of P-gp, LRP, BCRP and MRP.
Conclusion:
Above results indicated that AKBA might be a potential compound to reverse MDR in human ovarian cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP67416619-A	3-Acetyl-11-keto-β-boswellic acid		67416-61-9	Price

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