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3-aminobenzamide, One of poly(ADP-ribose)polymerase-1 Inhibitors, Rescuesapoptosisin Rat Models of Spinal Cord Injury

3-aminobenzamide, One of poly(ADP-ribose)polymerase-1 Inhibitors, Rescuesapoptosisin Rat Models of Spinal Cord Injury

Xianqing Meng, Wenqi Song, Bin Deng, Ziling Xing, Weihong Zhang

Int J Clin Exp Pathol. 2015 Oct 1;8(10):12207-15.

PMID: 26722405

Abstract:

Poly(ADP-ribose)polymerase-1 (PARP-1) is anubiquitous, DNA repair-associated enzyme, which participates in gene expression, cell death, central nerve system (CNS) disorders and oxidative stress. According to the previous studies, PARP-1 over-activation may lead to over-consumption of ATP and even cell apoptosis. Spinal cord injury (SCI) is an inducement towards PARP-1 over-activation due to its massive damage to DNA. 3-aminobenzamide (3-AB) is a kind of PARP-1 inhibitors. The relationship among PARP-1, 3-AB, SCI and apoptosis has not been fully understood. Hence, in the present study, we focused on the effects of 3-AB on cell apoptosis after SCI. Accordingly, SCI model was constructed artificially, and 3-AB was injected intrathecally into the Sprague-Dawley (SD) rats. The results demonstrated an increase in cell apoptosis after SCI. Furthermore, PARP-1 was over-activated after SCI but inhibited by 3-AB injection. In addition, apoptosis-inducing factor (AIF) was inhibited but B-cell lymphoma-2 (Bcl-2) was up-regulated by 3-AB. Interestingly, caspase-3 was not significantly altered with or without 3-AB. In conclusion, our experiments showed that 3-AB, as a PARP-1 inhibitor, could inhibit cell apoptosis after SCI in caspase-independent way, which could provide a better therapeutic target for the treatment of SCI.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3544249	3-Aminobenzamide		3544-24-9	Price

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