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3-Aminophenyl Boronic Acid-Functionalized CuInS2 Quantum Dots as a Near-Infrared Fluorescence Probe for the Determination of Dopamine

3-Aminophenyl Boronic Acid-Functionalized CuInS2 Quantum Dots as a Near-Infrared Fluorescence Probe for the Determination of Dopamine

Siyu Liu, Fanping Shi, Xiaojun Zhao, Lu Chen, Xingguang Su

Biosens Bioelectron. 2013 Sep 15;47:379-84.

PMID: 23608539

Abstract:

Water-soluble CuInS2 ternary quantum dots (QDs) capped by mercaptopropionic acid were directly synthesized in aqueous solution. Consequently, the CuInS2 QDs were covalently linked to 3-aminophenyl boronic acid molecules to form the 3-aminophenyl boronic acid-functionalized CuInS2 QDs (F-CuInS2 QDs). The F-CuInS2 QDs had a fairly symmetric fluorescence emission centered at 736nm that was in the near-infrared region (NIR). The F-CuInS2 QDs containing boronic acid functional groups were reactive toward vicinal diols to form five- or six-member cyclic esters in an alkaline aqueous solution. The reaction would cause the fluorescence quenching, which could be used as a fluorescence probe for the determination of dopamine (DA). This assay could also probe other vicinal diols such as catechol, pyrogallol, and gallate, based on the fluorescence quenching of the F-CuInS2 QDs, and this assay was nearly unaffected by other phenol compounds such as phenol, resorcinol, and hydroquinone without the vicinal diol structures. The developed F-CuInS2 QDs were applied to the detection of DA in human serum samples with satisfactory results. Therefore, this experment provided a simple and sensitve NIR fluorescence probe for the detection of DA, catechol, pyrogallol, and gallate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS793952	(3-phenylaminocarbonylphenyl)boronic acid			Price

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