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[3H]U-69593 a Highly Selective Ligand for the Opioid Kappa Receptor

[3H]U-69593 a Highly Selective Ligand for the Opioid Kappa Receptor

R A Lahti, M M Mickelson, J M McCall, P F Von Voigtlander

Eur J Pharmacol. 1985 Feb 26;109(2):281-4.

PMID: 2986999

Abstract:

The selective kappa agonist U-50488 was recently discovered and characterized. In this study, the receptor binding properties of [3H]U-69593, an analog of U-50488, were characterized. [3H]U-69593 binds with high affinity (3 nM) to membranes prepared from guinea pig, mouse and rat brain. The number of kappa binding sites comprise only 13%, 9% and 4% of the total opioid sites, respectively. The benzmorphans, dynorphin, and compounds structurally related to U-50488 have high affinity for this kappa site.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP96744751	U-69593		96744-75-1	Price

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