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4-Arylvinyl-2,6-di(pyridin-2-yl)pyrimidines: Synthesis and Optical Properties

4-Arylvinyl-2,6-di(pyridin-2-yl)pyrimidines: Synthesis and Optical Properties

Caroline Hadad, Sylvain Achelle, Joaquín C García-Martinez, Julián Rodríguez-López

J Org Chem. 2011 May 20;76(10):3837-45.

PMID: 21462944

Abstract:

A series of 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines have been efficiently prepared by a double cross-coupling reaction between 2,4-dichloro-6-methylpyrimidine and 2-(tributylstannyl)pyridine, followed by aldol condensation with the appropriate aromatic aldehyde substituted with electron-donating, electron-withdrawing, dendritic, or water-soluble groups. The effect of different protic and aprotic solvents on the optical absorption and emission properties of these systems was studied. Compounds with electron-donating groups display strong emission solvatochromism, suggesting the formation of an intramolecular charge-separated emitting state. The solvatochromic behavior depends not only on the solvent polarity but also on the hydrogen bonding parameters of the solvent. The effect of protonation was also studied, and the abilities of some of these molecules to function as colorimetric and luminescent pH sensors were demonstrated with dramatic color changes and luminescence switching upon the introduction of acid.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17997476	2-(Tributylstannyl)pyridine		17997-47-6	Price

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