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4-hexylresorcinol Exerts Antitumor Effects via Suppression of Calcium Oscillation and Its Antitumor Effects Are Inhibited by Calcium Channel Blockers

4-hexylresorcinol Exerts Antitumor Effects via Suppression of Calcium Oscillation and Its Antitumor Effects Are Inhibited by Calcium Channel Blockers

Seong-Gon Kim, Je-Yong Choi

Oncol Rep. 2013 May;29(5):1835-40.

PMID: 23427012

Abstract:

The bacterial dormancy-inducing factor 4-hexylresorcinol (4-HR) has been shown to have synergistic antitumor effects when used in combination with cisplatin. In the present study, 4-HR was used as a single agent in the squamous carcinoma cell line SCC-9. The results demonstrated that 4-HR suppressed SCC-9 cell proliferation compared to primary cultured gingival fibroblasts. 4-HR dose-dependently induced SCC-9 cell apoptosis as determined by caspase-3 activity, annexin V expression, as well as by scanning and transmission electron microscopy. 4-HR inhibited intracellular calcium oscillation in both SCC-9 cells and normal human dermal fibroblasts. 4-HR-induced apoptosis was partly reversed by calcium channel blockers. Of note, 4-HR reduced the tumor mass formed by SSC-9 cell implantation in BALB/cAnNCrj-nu/nu mice and mass size reduction was also partly reversed by the concomitant application of calcium channel blockers. Collectively, our results suggest that 4-HR has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP136776-A	4-Hexylresorcinol		136-77-6	Price

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