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4-Hexylresorcinol Inhibits transglutaminase-2 Activity and Has Synergistic Effects Along With Cisplatin in KB Cells

4-Hexylresorcinol Inhibits transglutaminase-2 Activity and Has Synergistic Effects Along With Cisplatin in KB Cells

Seong-Gon Kim, Jae-Hwan Jeong, Young-Wook Park, Ji-Young Song, An-Sook Kim, Je-Yong Choi, Weon-Sik Chae

Oncol Rep. 2011 Jun;25(6):1597-602.

PMID: 21424127

Abstract:

Resistance to chemotherapy is very important in the prognosis of tumors. Transglutaminase-2 (TG-2) mediated chemotherapy resistance has been widely reported. The objective of this study was to demonstrate the effect of 4-hexylresorcinol (4-HR) on TG-2 activity in nasopharyngeal squamous cell carcinoma cells (KB cells). Treatment with a mixture of 4-HR and cisplatin significantly decreased KB cell viability compared to treatment by cisplatin alone at 10 µg/ml (p<0.001). 4-HR inhibited TG-2 activity compared to cisplatin alone at 5, 10 and 20 µg/ml (p = 0.001, 0.001 and 0.003, respectively). Nuclear translocation of TG-2 was also inhibited by 4-HR treatment. 4-HR treatment also increased the fluorescence life-time of DAPI significantly compared to the untreated control or the cisplatin treated group (p<0.001). In conclusion, 4-HR inhibited TG-2 activity and showed a synergistic effect on tumor cell growth inhibition with cisplatin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP136776-A	4-Hexylresorcinol		136-77-6	Price

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