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4Alpha-bromo-5alpha-cholestan-3beta-ol and nor-5alpha-cholestan-3beta-ol Derivatives-Stereoselective Synthesis and Hormonal Activity in Caenorhabditis Elegans

René Martin, Ratni Saini, Ingmar Bauer, Margit Gruner, Olga Kataeva, Vyacheslav Zagoriy, Eugeni V Entchev, Teymuras V Kurzchalia, Hans-Joachim Knölker

Org Biomol Chem. 2009 Jun 7;7(11):2303-9.

PMID: 19462039

Abstract:

We describe the stereoselective synthesis of 4alpha-bromo-5alpha-cholestan-3beta-ol, 21-nor-5alpha-cholestan-3beta-ol, 27-nor-5alpha-cholestan-3beta-ol and 21,27-bisnor-5alpha-cholestan-3beta-ol. In order to clarify the in vivo metabolism of cholesterol, these compounds have been used for feeding experiments in Caenorhabditis elegans. Our preliminary results provide important insights into the metabolism of cholesterol in worms.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP80977 5α-Cholestan-3β-ol 5α-Cholestan-3β-ol 80-97-7 Price
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