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5,7-Dihydroxychromone-2-carboxylic Acid and It's Transition-Metal (Mn and Zn) Chelates as Non-Thiol Radioprotective Agents

5,7-Dihydroxychromone-2-carboxylic Acid and It's Transition-Metal (Mn and Zn) Chelates as Non-Thiol Radioprotective Agents

Seyed Jalal Hosseinimehr, Saeed Emami, Seyed Mohammad Taghdisi, Shahram Akhlaghpoor

Eur J Med Chem. 2008 Mar;43(3):557-61.

PMID: 17602799

Abstract:

5,7-Dihydroxychromone-2-carboxylic acid (DHCCA) and its related complexes with manganese and zinc were prepared and evaluated for radioprotection activity against gamma irradiation in mice. The LD(50) values were found to be more than 1500 and 1000 mg/kg for DHCCA and it's complexes, respectively. For studying radioprotective effects, 1.0 mmol/kg and 0.5 mmol/kg doses of compounds were administrated subcutaneously 24 h prior to 8.2 Gy gamma irradiation. The percentages of 30-day survival of mice for these compounds were 26%-50%. DHCCA exhibited significant action in delaying deaths as well as effective protection against gamma rays-induced mortality compared to reference drug amifostine. Amifostine provides effective radiation protection when administrated immediately prior to radiation exposure, but administration of DHCCA, even 24 h prior to gamma irradiation, provides a significant protection.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP31721945	5,7-Dihydroxychromone		31721-94-5	Price

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