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5-Bromo-2'-deoxyuridine Impairs Long-Term Food Aversion Memory in Edible Snail

5-Bromo-2'-deoxyuridine Impairs Long-Term Food Aversion Memory in Edible Snail

O I Efimova, K V Anokhin

Bull Exp Biol Med. 2012 Sep;153(5):767-70.

PMID: 23113281

Abstract:

We studied the involvement of DNA synthesis into molecular mechanisms of long-term memory. Nucleoside analogue 5-bromo-2'-deoxyuridine (BrdU) is known to incorporate into synthesizing DNA and prevent subsequent DNA replication from this region. To investigate the effect of BrdU administration on long-term memory, terrestrial gastropods edible snails Helix lucorum were trained in the food aversion paradigm. Single-session training (carrot presentation combined with application of 10% quinine solution, three carrot presentations with 10-min intervals) resulted in the formation of long-term memory that persisted for at least 45° days. BrdU administration (250 mg/kg) 30 min before training impaired long-term memory tested 24 h later. Immunohistochemical study revealed BrdU incorporation in the nuclei of identified neurons of defensive behavior.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP59143	5-Bromo-2′-deoxyuridine		59-14-3	Price

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