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[5-HT1A/5-HT7 Receptor Interplay: Chronic Activation of 5-HT7 Receptors Decreases the Functional Activity of 5-HT1A Receptor and Its сontent in the Mouse Brain]

[5-HT1A/5-HT7 Receptor Interplay: Chronic Activation of 5-HT7 Receptors Decreases the Functional Activity of 5-HT1A Receptor and Its сontent in the Mouse Brain]

E M Kondaurova, D V Bazovkina, V S Naumenko

Mol Biol (Mosk). Jan-Feb 2017;51(1):157-165.

PMID: 28251979

Abstract:

Serotonin receptors 5-HT1A and 5-HT7 are involved in the development of various psychopathologies. Some data indicate that there is an interplay between 5-HT1A 5-HT7 receptors that could be implicated in the regulation of their function. This work analyzed the effects of chronic 5-HT7 activation on the functional activity of 5-HT7 and 5-HT1A receptors, on the corresponding protein levels, and on the expression of genes encoding 5-HT7 and 5-HT1A receptors in the mouse brain. Chronic administration of the 5-HT7 selective agonist LP44 (20.5 nmol, i.c.v., 14 days) produced considerable desensitization of both 5-HT7 and 5-HT1A receptors. In LP44-treated mice, the hypothermic responses mediated by both 5-HT7 and 5-HT1A receptors were attenuated. Moreover, the levels of 5-HT1A receptor protein in the midbrain and the frontal cortex of LP44-treated mice were significantly decreased. However, the brain levels of 5-HT7 receptor protein did not differ between LP44-treated and control mice. Chronic LP44 treatment did not alter the expression of the 5-HT7 and 5-HT1A receptor genes in all investigated brain structure. These data suggest that 5-HT7 receptors participate in the posttranscriptional regulation of the 5-HT1A receptors functioning.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP824958125	LP44		824958-12-5	Price

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