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5-Methylurapidil May Discriminate Between Alpha 1-adrenoceptors With a High Affinity for WB4101 in Rat Lung

5-Methylurapidil May Discriminate Between Alpha 1-adrenoceptors With a High Affinity for WB4101 in Rat Lung

Y Hiramatsu, R Muraoka, S Kigoshi, I Muramatsu

Br J Pharmacol. 1992 Jan;105(1):6-7.

PMID: 1350746

Abstract:

The alpha 1-adrenoceptors of rat lung with a high affinity for [3H]-prazosin were subdivided into two populations (high and low affinity sites) by WB4101 and 5-methylurapidil but the proportions were different between both drugs. After pretreatment with chlorethylclonidine, WB4101 recognized only high affinity sites, while 5-methylurapidil still detected high and low affinity sites. These results indicate that alpha 1-adrenoceptors with a high affinity for WB4101 are not homogeneous in the rat lung, suggesting the possible existence of a new alpha 1-adrenoceptor subtype in addition to alpha 1A and alpha 1B subtypes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP34661853	5-Methylurapidil		34661-85-3	Price

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