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5-(N-Ethyl-N-isopropyl)-amiloride Inhibits Amino Acid Release From the Ischemic Rat Cerebral Cortex: Role of Na+-H+ Exchange

5-(N-Ethyl-N-isopropyl)-amiloride Inhibits Amino Acid Release From the Ischemic Rat Cerebral Cortex: Role of Na+-H+ Exchange

J W Phillis, M H O'Regan, D Song

Brain Res. 1998 Nov 23;812(1-2):297-300.

PMID: 9813378

Abstract:

The effect of the selective Na+/H+ antiporter inhibitor 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) on amino acid release from the ischemic/reperfused rat cerebral cortex was investigated using a cortical cup technique. EIPA (25 microM in artificial cerebrospinal fluid), applied topically, inhibited the ischemia-reperfusion evoked efflux of aspartate, glutamate, gamma-aminobutyric acid, taurine and phosphoethanolamine. Reductions in the ischemia-evoked releases of these amino acids suggest that ischemia precipitates acidosis, Na+/H+ exchange and cell swelling with amino acid release as the cells mount a regulatory volume decrease response. EIPA, by blocking Na+/H+ exchange, would reduce cell swelling and the resulting amino acid release.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1154252	5-(N-Ethyl-N-isopropyl)amiloride		1154-25-2	Price

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