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5'-(N-ethylcarboxamido) Adenosine Improves Angiogenesis in Transplanted Human Ovarian Tissue

5'-(N-ethylcarboxamido) Adenosine Improves Angiogenesis in Transplanted Human Ovarian Tissue

Maryam Hormozi, Saeed Talebi, Amir Hassan Zarnani, Mahmood Jeddi-Tehrani, Ladan Hosseini Gohari, Haleh Soltanghoraei, Mina Jafarabadi, Mohammad Mehdi Akhondi

Fertil Steril. 2011 Jun 30;95(8):2560-3.e1-5.

PMID: 21704211

Abstract:

To investigate the effect of 5'-(N-ethylcarboxamido) adenosine (NECA), an adenosine agonist, on triggering angiogenesis in transplanted human ovarian tissue, the expression of angiopoietin-1 (Ang1), Ang2, vascular endothelial growth factor 121 (VEGF-121) and VEGF-189 at both gene and protein levels as well as the density of vasculature were studied in tissue fragments grafted to NECA-treated and control groups of nude mice. The results showed that NECA treatment triggered down-regulation of Ang1, induced VEGF-189 expression, and stimulated neovascularization, highlighting the beneficial effect of NECA on the process of angiogenesis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP35920399	5′-(N-Ethylcarboxamido)adenosine		35920-39-9	Price

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