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6-Gingerol Attenuates LPS-induced Neuroinflammation and Cognitive Impairment Partially via Suppressing Astrocyte Overactivation

6-Gingerol Attenuates LPS-induced Neuroinflammation and Cognitive Impairment Partially via Suppressing Astrocyte Overactivation

Feng Zhang, Ji-Guo Zhang, Wei Yang, Pu Xu, Yu-Liang Xiao, Han-Ting Zhang

Biomed Pharmacother. 2018 Nov;107:1523-1529.

PMID: 30257370

Abstract:

6-Gingerol, the major component of gingerols extracted from Zingiber officinale, has been shown to exhibit anti-inflammatory and antioxidant bioactivities. Since neuroinflammation plays an important role in neurodegenerative diseases, such as Alzheimer's disease (AD), and astrocytes have been considered important in the process of neurodegeneration, it was of interest to know whether 6-gingerol reduced astrocytes activation or even attenuated cognitive impairment. Here we examined the neuroprotective effects of 6-gingerol in lipopolysaccharide (LPS)-induced disorder models both in vitro and in vivo. C6 astroglioma cells treated with LPS were found to release excessive pro-inflammatory cytokines, including TNF-α and IL-6, and also increase intercellular ROS, NO, and iNOS (i.e. NOS2). All these were blocked by 6-gingerol in a concentration-dependent manner. The spatial learning and memory of rats challenged with LPS (10 μg, i.c.v.) in the absence or presence of 6-gingerol were evaluated using the Morris water-maze (MWM) test. 6-Gingerol attenuated LPS-induced imapirement of MWM learning and memory in a dose-dependent manner. Besides, 6-gingerol inhibited LPS-induced increases in levels of GFAP and TNF-α in the rat brain. The results suggest that 6-gingerol suppresses astrocyte overactivation, through which it contributes to improvement of cognitive ability.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23513146-A	[6]-Gingerol		23513-14-6	Price
AP23513146-B	6-Gingerol		23513-14-6	Price

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