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6-Shogaol Attenuates LPS-induced Inflammation in BV2 Microglia Cells by Activating PPAR-γ

6-Shogaol Attenuates LPS-induced Inflammation in BV2 Microglia Cells by Activating PPAR-γ

Qinghe Han, Qinghai Yuan, Xiaolin Meng, Junyuan Huo, Yuxin Bao, Guanghong Xie

Oncotarget. 2017 Jun 27;8(26):42001-42006.

PMID: 28410218

Abstract:

6-Shogaol, a pungent agent isolated from Zingiber officinale Roscoe, has been known to have anti-tumor and anti-inflammatory effects. However, the anti-inflammatory effects and biological mechanism of 6-Shogaol in LPS-activated BV2 microglia remains largely unknown. In this study, we evaluated the anti-inflammatory effects of 6-Shogaol in LPS-activated BV2 microglia. 6-Shogaol was administrated 1 h before LPS treatment. The production of inflammatory mediators were detected by ELISA. The expression of NF-κB and PPAR-γ were detected by western blot analysis. Our results revealed that 6-Shogaol inhibited LPS-induced TNF-α, IL-1β, IL-6, and PGE2 production in a concentration dependent manner. Furthermore, 6-Shogaol inhibited LPS-induced NF-κB activation by inhibiting phosphorylation and nuclear translocation of NF-κB p65. In addition, 6-Shogaol could increase the expression of PPAR-γ. Moreover, inhibition of PPAR-γ by GW9662 could prevent the inhibition of 6-Shogaol on LPS-induced inflammatory mediator production. In conclusion, 6-Shogaol inhibits LPS-induced inflammation by activating PPAR-γ.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP555668	[6]-Shogaol		555-66-8	Price

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