Home
Resources
Publications
7, 8-dihydroxycoumarin Improves Neurological Function in a Mouse Model of Sciatic Nerve Injury

7, 8-dihydroxycoumarin Improves Neurological Function in a Mouse Model of Sciatic Nerve Injury

Jianshi Du, Qing Zhao, Yingli Zhang, Yu Wang, Ming Ma

Neural Regen Res. 2012 Feb 25;7(6):445-50.

PMID: 25774187

Abstract:

In the present study, a mouse model of sciatic nerve injury was treated with intraperitoneal injection of 7, 8-dihydroxycoumarin (10, 5, or 2.5 mg/kg per day). Western blot and real-time PCR results showed that growth associated protein 43 expression was significantly increased in the L4-6 segments of the spinal cord. The amplitude and velocity of motor nerve conduction in the sciatic nerve were significantly increased in model mice. In addition, the appearance of the myelin sheath in the injured sciatic nerve was regular, with an even thickness and clear outline, and the surrounding fibroplasia was not obvious. Our results indicate that 7, 8-dihydroxycoumarin can promote the repair of injured nerve by upregulating growth associated protein 43 expression in the corresponding spinal cord segments of mice with sciatic nerve injury.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP486351-B	7,8-Dihydroxycoumarin		486-35-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: