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8-Cyclopentyl 1,3-dimethylxanthine Prolongs Epileptic Seizures in Rats

M Dragunow, H A Robertson

Brain Res. 1987 Aug 11;417(2):377-9.

PMID: 3651821

Abstract:

We tested the effects of 8-cyclopentyl-1,3 dimethylxanthine (8-CPT) on electrically induced seizures in rats. 8-CPT prolonged secondary seizures and converted partial seizures into generalized motor seizures, but did not affect primary seizure duration. Because 8-CPT is a potent and specific adenosine antagonist, these results add further support to the hypothesis that endogenous adenosine prevents the spread of epileptic seizures.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP35873495 8-Cyclopentyl-1,3-dimethylxanthine 8-Cyclopentyl-1,3-dimethylxanthine 35873-49-5 Price
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