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[8]-Gingerol Inhibits Melanogenesis in Murine Melanoma Cells Through Down-Regulation of the MAPK and PKA Signal Pathways

[8]-Gingerol Inhibits Melanogenesis in Murine Melanoma Cells Through Down-Regulation of the MAPK and PKA Signal Pathways

Huey-Chun Huang, Yin-Chun Chou, Chia-Yin Wu, Tsong-Min Chang

Biochem Biophys Res Commun. 2013 Aug 23;438(2):375-81.

PMID: 23892040

Abstract:

[8]-Gingerol is an active component of Zinger and shows several pharmacological activities, such as antipyretic and anti-inflammation characteristics. To identify a potential skin-whitening agent, the inhibitory effects of [8]-gingerol on melanogenesis and its mechanism of action were investigated. In the present study, the effects of [8]-gingerol on mushroom tyrosinase, tyrosinase activity and melanin content were determined spectrophotometrically; the expression of melanogenesis-related proteins in B16F10 and B16F1 melanoma cells were determined by Western blotting. Furthermore, the possible signaling pathways involved in [8]-gingerol-mediated depigmentation were also investigated using specific inhibitors. The results revealed that [8]-gingerol (5-100μM) effectively suppressed intracellular tyrosinase activity and decreased the amount of melanin in B16F10 and B16F1 cells. In addition, [8]-gingerol also effectively decreased intracellular reactive species (RS) and reactive oxygen species (ROS) levels at the same dose range. Our results indicated that [8]-gingerol inhibited melanogenesis in B16F10 and B16F1 cells by down-regulation of both mitogen-activated protein kinases (MAPK) and protein kinase A (PKA) signaling pathways or through its antioxidant properties. Hence, [8]-gingerol could be used as an effective skin-whitening agent.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23513088	[8]-Gingerol		23513-08-8	Price

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