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9-cis-canthaxanthin Exhibits Higher Pro-Apoptotic Activity Than All-Trans-Canthaxanthin Isomer in THP-1 Macrophage Cells

9-cis-canthaxanthin Exhibits Higher Pro-Apoptotic Activity Than All-Trans-Canthaxanthin Isomer in THP-1 Macrophage Cells

Vijayalatha Venugopalan, Nandini Verma, Hemant K Gautam, P Pardha Saradhi, Rakha H Das

Free Radic Res. 2009 Feb;43(2):100-5.

PMID: 19148843

Abstract:

All-trans-canthaxanthin (4, 4'-diketo beta-carotene) but not 9-cis-canthaxanthin has been shown to induce apoptosis in some cell lines. In this study apoptotic activity of 9-cis-canthaxanthin on THP-1 macrophage is reported. Comparison of apoptotic activities of the two canthaxanthin isomers on this cell line by annexin V-cy3 and TUNEL assays indicated the higher pro-apoptotic activity of 9-cis-isomer than the all-trans-isomer. Canthaxanthin-induced apoptosis in this cell line was found to be accompanied by increased caspase-3 and caspase-8 activities, indicating its progression via caspase cascade. Induction of both caspase activities was higher by 9-cis-canthaxanthin than that by trans-canthaxanthin. All these results suggest that canthaxanthin stereoisomers differentially induce apoptosis of THP-1 monocyte/macrophage.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP514783	Canthaxanthin (trans)		514-78-3	Price

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