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99mTc-labeling Experiments on CCK(4) by a Direct Method

99mTc-labeling Experiments on CCK(4) by a Direct Method

R Rossin, D Blok, R Visentin, R I Feitsma, M C Giron, E K Pauwels, U Mazzi

Nucl Med Biol. 2001 Oct;28(7):865-73.

PMID: 11578909

Abstract:

99mTc-labeling studies have been performed on CCK(4) fragment of cholecystokinin, starting from 99mTc-pertechnetate, by using tin(II)pyrophosphate or tin(II)gluconate as reducing agents, together with NaBH(4) acting as a stabilizing agent of tin(II). Gluconate has been used as exchange ligand in the carrier added experiments and in the syntheses of 99Tc-CCK(4) and Re-CCK(4) complexes to be able to reproduce at macroscopic level the same chemical reactions occurring at non carrier added conditions. 99mTc-labeling yields higher than 95% have been achieved depending on Sn(II) concentration, CCK(4)/gluconate ratio, reaction time and applied temperature. The species produced with 99mTc, 99Tc, and cold rhenium nuclides have been compared by means of HPLC measurements, which showed similar retention times and thus probably the same species in the three situations.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7932121	Tin(II) pyrophosphate			Price

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