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A 1-year Randomized Trial of Deferasirox Alone Versus Deferasirox and Deferoxamine Combination for the Treatment of Iron Overload in Thalassemia Major

A 1-year Randomized Trial of Deferasirox Alone Versus Deferasirox and Deferoxamine Combination for the Treatment of Iron Overload in Thalassemia Major

Aziz Eghbali, Pooria Shokri, Roghayeh Rahimi Afzal, Bahador Bagheri

Transfus Apher Sci. 2019 Aug;58(4):429-433.

PMID: 31229401

Abstract:

Aim:
Iron chelators are extensively used to reduce iron overload. Our purpose was to compare effects of deferasirox versus deferasirox and deferoxamine in patients with thalassemia major.
Methods:
This randomized and double blind trial was performed on 62 patients. Patients were assigned 1:1 to oral 30 mg/kg deferasirox daily or oral 30 mg/kg deferasirox daily plus SC 50 mg/kg deferoxamine for 5 days a week. Treatment continued for 12 months in both groups.
Results:
Fifty-five patients completed the 1 year of treatment. Mean age was 24.5 years with an excess of females. Combined therapy caused a significant increase in myocardial T2* from 23.1 ± 7.5 ms at baseline to 27.1 ± 7.0 ms at 12 months (P < 0.05). This difference was statistically significant between 2 groups at 12 months (P = 0.01). Combined therapy and monotherapy had no significant effect on liver T2*. At 12 months, serum ferritin levels were reduced in two groups; however, the difference was significant (737 ± 459 μg/ml vs 1085 ± 919 μg/ml, P < 0.01).
Conclusion:
Our study indicates that combined treatment with deferasirox and deferoxmaine is more effective than deferasirox for reduction of iron over load in patients with thalassemia major.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31041270	Deferasirox			Price

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