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A 2-Hydroxypyridine Catabolism Pathway in Rhodococcus Rhodochrous Strain PY11

A 2-Hydroxypyridine Catabolism Pathway in Rhodococcus Rhodochrous Strain PY11

Justas Vaitekūnas, Renata Gasparavičiūtė, Rasa Rutkienė, Daiva Tauraitė, Rolandas Meškys

Appl Environ Microbiol. 2015 Dec 11;82(4):1264-1273.

PMID: 26655765

Abstract:

Rhodococcus rhodochrous PY11 (DSM 101666) is able to use 2-hydroxypyridine as a sole source of carbon and energy. By investigating a gene cluster (hpo) from this bacterium, we were able to reconstruct the catabolic pathway of 2-hydroxypyridine degradation. Here, we report that in Rhodococcus rhodochrous PY11, the initial hydroxylation of 2-hydroxypyridine is catalyzed by a four-component dioxygenase (HpoBCDF). A product of the dioxygenase reaction (3,6-dihydroxy-1,2,3,6-tetrahydropyridin-2-one) is further oxidized by HpoE to 2,3,6-trihydroxypyridine, which spontaneously forms a blue pigment. In addition, we show that the subsequent 2,3,6-trihydroxypyridine ring opening is catalyzed by the hypothetical cyclase HpoH. The final products of 2-hydroxypyridine degradation in Rhodococcus rhodochrous PY11 are ammonium ion and α-ketoglutarate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP142085	2-Hydroxypyridine		142-08-5	Price

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