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A Bioactive Fullerene Peptide

A Bioactive Fullerene Peptide

C Toniolo, A Bianco, M Maggini, G Scorrano, M Prato, M Marastoni, R Tomatis, S Spisani, G Palú, E D Blair

J Med Chem. 1994 Dec 23;37(26):4558-62.

PMID: 7799406

Abstract:

The highly hydrophobic C60 (buckminsterfullerene) was water solubilized by covalently linking the synthon 1,2-dihydro-1,2-methanofullerene [60]-61-carboxylic acid to the alpha-amino group of the hydrophilic 4-8 sequence of peptide T, known to display potent human monocyte chemotaxis. The resulting compound, characterized by a variety of analytical techniques, including a UV spectrum in aqueous solution, exhibits remarkable chemotactic potency, comparable to that of the parent pentapeptide. Furthermore, this fullerene-peptide conjugate inhibits, albeit weakly, HIV-1 protease.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP155116191	(1,2-Methanofullerene C60)-61-carboxylic acid		155116-19-1	Price

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