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A Boron-Containing Estrogen Mimic

P D Robinson, M P Groziak

Acta Crystallogr C. 1999 Oct 15;55 ( Pt 10):1701-4.

PMID: 10573830

Abstract:

A prototype of a new class of 2,3,1-benzodiazaborine-based estrogen mimics is described. 1,2-Dihydro-1,6-dihydroxy-2-(2-methoxy-6-pyridyl)-2,3,1-benzodiazabor ine, (6), was obtained as a crystalline monohydrate (C13H12BN3O3.H2O) after regioselective BBr3-mediated O-demethylation of the condensation product formed from 2-formyl-4-methoxybenzeneboronic acid and 2-hydrazino-6-methoxypyridine. As intended by design, the solid-state structure of (6) features an intramolecular hydrogen-bond association between the donor B--OH group and the acceptor pyridine ring N, a connection which constitutes an additional 'virtual' six-membered ring, thereby providing for an overall topography closely matching that of a tetracyclic steroid. Specifically, prototype (6) can be viewed as a boron-containing mimic of the O17-methyl ether derivatives of dihydroequilenin or estradiol.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP94838887 2-Formyl-4,5-methylenedioxyphenylboronic acid 2-Formyl-4,5-methylenedioxyphenylboronic acid 94838-88-7 Price
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