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A Boronic Acid Modified Binary Matrix Consisting of Boron Nitride and α-cyano-4-hydroxycinnamic Acid for Determination of Cis-Diols by MALDI-TOF MS

A Boronic Acid Modified Binary Matrix Consisting of Boron Nitride and α-cyano-4-hydroxycinnamic Acid for Determination of Cis-Diols by MALDI-TOF MS

Ya-Shun Chen, Hua-Ming Xiao, Tian-Qi Wang, Lei Yu, Yu-Qi Feng

Mikrochim Acta. 2019 Aug 1;186(8):591.

PMID: 31372763

Abstract:

A MALDI-TOF mass spectrometric method is described for the determination of small molecule compounds with cis-diol. It is based on the use of a binary matrix consisting of boron nitride (BN) and α-cyano-4-hydroxycinnamic acid that was modified with the derivatization reagent of (3-(acridin-9-ylamino)phenyl)boronic acid which can recognize cis-diols. The binary matrix is used for desorption/ionization (DI) in the positive ion mode. The mechanism leading to DI enhancement was investigated. The results imply that BN is beneficial for the DI because it induces an enhancement in the positive ion mode. The boronic acid-functionalized binary matrix was successfully applied to capture the glucose, shikimic acid and quinic acid. The method was applied to the determination of 3-chloro-1,2-propanediol in plant oil. Graphical abstract Schematic representation of a method for detecting the cis-diol compounds on matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) using the binary matrix of boron nitride (BN)/α-cyano-4-hydroxycinnamic acid (CHCA) that was modified with (3-(acridin-9-ylamino)phenyl) boronic acid (AYPBA).

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP28166418	α-Cyano-4-hydroxycinnamic acid	28166-41-8	Price
LS7931253	5-cyano-3-pyridinyl boronic acid		Price
LS793857	[4-(1-Piperidin-1-ylethyl)phenyl]boronic acid		Price

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