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A Colorimetric Titration Method for Quantification of Millimolar Glucose in a pH 7.4 Aqueous Phosphate Buffer

Serhan Boduroglu, Jouliana M El Khoury, D Venkat Reddy, Peter L Rinaldi, Jun Hu

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3974-7.

PMID: 16039121

Abstract:

3-Pyridinylboronic acid is identified as a key sensing element for reversible sugar complexation in an aqueous solution at the physiological pH. The utility of a sensing element has been demonstrated through a simple colorimetric titration of glucose using absorption spectroscopy in the visible region. The mechanism of the high diol/triol binding affinity of pyridine boronic acid in the neutral pH is discussed based on the 1H and 11B NMR spectroscopic studies.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1692257 3-Pyridinylboronic acid 3-Pyridinylboronic acid 1692-25-7 Price
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