Home
Resources
Publications
A Comparative Anticancer Study on Procyanidin C1 Against Receptor Positive and Receptor Negative Breast Cancer

A Comparative Anticancer Study on Procyanidin C1 Against Receptor Positive and Receptor Negative Breast Cancer

Laxmi L Koteswari, Seema Kumari, Anil B Kumar, Rama Rao Malla

Nat Prod Res. 2019 Jan 8;1-8.

PMID: 30618284

Abstract:

Albezia odoratissima has many health benefits. The present study investigated the isolation, characterization and anticancer activity of procyanidin C1 from A. odoratissima bark. Procyanidin C1 was isolated and characterized by IR, 13C NMR, 1H NMR and LC-MS spectroscopic studies. Anticancer property of procyanidin C1 was explored by studying the expression of checkpoint kinases, Bcl-2 and BAX, cell cycle, DNA damage and caspase 3 and 9 levels. Procyanidin C1 exhibited significant cytotoxicity against TNBC (MDA-MB- 231), hormone positive (MCF-7) cell lines. Its IC50 value is comparable to tamoxifen towards MDA-MB- 231 cell line, but considerably higher towards MCF-7 cell line. Procyanidin C1 induced DNA damage, cell cycle arrest and enhanced the expression of checkpoint kinases. Procyanidin C1 decreased the level of Bcl-2 but increased the BAX, caspase 3 and 9 expression in cancer cells. This study indicates the antiproliferative property of procyanidin C1 against breast cancer cells by inducing apoptosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP37064305	Procyanidin C1		37064-30-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: