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A Comparative Study of Edetate Calcium Disodium and Dimercaptosuccinic Acid in the Treatment of Lead Poisoning in Adults

A Comparative Study of Edetate Calcium Disodium and Dimercaptosuccinic Acid in the Treatment of Lead Poisoning in Adults

Kirushanthi Sakthithasan, Pierre Lévy, Joël Poupon, Robert Garnier

Clin Toxicol (Phila). 2018 Nov;56(11):1143-1149.

PMID: 29889577

Abstract:

Background:
We evaluated the efficacy of two antidotes, edetate calcium disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults.
Methods:
Thirty-seven patients with blood lead concentrations >40 μg/dL and positive CaNa2EDTA lead mobilization were randomized to receive 1050 mg/m2/day of oral DMSA (n = 21) or 500 mg/m2/day of intravenous CaNa2EDTA (n = 16) over two five-day courses separated by a 10-day rest period. Efficacy of treatment was evaluated by blood lead assays on the first day of the two courses and 14 days after the end of treatment and baseline CaNa2EDTA lead mobilization test and 14 days after the end of treatment.
Results and conclusion:
Both treatments significantly reduced the prevalence of clinical symptoms, blood lead levels and CaNa2EDTA lead mobilization and were well tolerated. DMSA had a greater impact on reducing blood lead concentrations (p = .005) and CaNa2EDTA on lead mobilization (p = .04). Comparison of equimolar doses showed that CaNa2EDTA was more effective than DMSA (p < .001).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23411349-A	Edetate Calcium Disodium		23411-34-9	Price

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