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A Comparison of the Effects of Methylprednisolone Acetate, Sodium Hyaluronate and Tenoxicam in the Treatment of Non-Reducing Disc Displacement of the Temporomandibular Joint

A Comparison of the Effects of Methylprednisolone Acetate, Sodium Hyaluronate and Tenoxicam in the Treatment of Non-Reducing Disc Displacement of the Temporomandibular Joint

G Yapici-Yavuz, G Şimşek-Kaya, H Oğul

Med Oral Patol Oral Cir Bucal. 2018 May 1;23(3):e351-e358.

PMID: 29680845

Abstract:

Background:
This clinical study aimed to radiologically and clinically compare the effect of intra-articular injection of methylprednisolone, sodium hyaluronate or tenoxicam following arthrocentesis with that of arthrocentesis alone in patients with non-reducing disc displacement.
Material and methods:
A total of 44 patients radiographically diagnosed with non-reducing disc displacement of the temporomandibular joint (TMJ) were randomly divided into four treatment groups, as follows: Group 1, arthrocentesis alone; Group 2, arthrocentesis plus methylprednisolone acetate; Group 3, arthrocentesis plus sodium hyaluronate; Group 4, arthrocentesis plus tenoxicam. Maximum mouth opening (MMO), lateral movement, pain severity and tenderness of TMJ and muscles of mastication on palpation were measured before treatment and at 1 week and 1, 3 and 6 months after treatment. Disc position, presence or absence of disc reduction, level of effusion, joint movement and joint space were also evaluated using magnetic resonance imaging (MRI) before treatment and 6 months after treatment.
Results:
No significant differences in treatment success were found among the four groups. MRI findings did not vary significantly among the groups, but pre- and post-operative MRI findings varied significantly within all four groups (p<0.001).
Conclusion:
According to the data from this study, it may be concluded that either arthrocentesis alone or arthrocentesis with methylprednisolone acetate or sodium hyaluronate or tenoxicam intra-articular injections are similarly effective and promising methods in the treatment of TMJ with non-reducing disc displacement.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP53361-A	Methylprednisolone Acetate		53-36-1	Price

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