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A Concise Synthesis of Peramine, a Metabolite of Endophytic Fungi

Shinsaku Ito, Yuta Yamamoto, Toshio Nishikawa

Biosci Biotechnol Biochem. 2018 Dec;82(12):2053-2058.

PMID: 30200859

Abstract:

The total synthesis of peramine, a natural product isolated from an endophytic fungi, has been achieved in four steps and 34% overall yield from known compounds. The key step was the one-pot construction of the pyrrolopyrazinone ring from pyrrole amide and propargyl bromide. The preparation of peramine-d4 as an internal standard for quantitative analysis by MS is also described.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP19244985 Guanidinium bromide Guanidinium bromide 19244-98-5 Price
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