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A Convenient Identification of Carbamate-Derived Drug Substances

A Convenient Identification of Carbamate-Derived Drug Substances

B Lohrer, F Bracher

Pharmazie. 2018 Oct 1;73(10):555-558.

PMID: 30223917

Abstract:

The "second identification" of drugs in pharmacies and hospital pharmacies affords the availability of easy to perform and robust tests. Besides determination of melting points and simple chromatography (TLC), reliable color and precipitation reactions are common techniques for this purpose. Preferentially, these reactions allow for the identification of typical functional groups in the drugs. Here we present a reaction for identification of carbamate-type drugs, based on the precipitation of barium carbonate upon treating the analytes with barium hydroxide solution at 80 °C. This method works well for carbamate drugs with noteworthy water solubility like carbachol, neostigmine bromide, and pyridostigmine bromide, and could be considered as a method for second identification of these drugs in pharmacopoeias and in Deutscher Arzneimittel-Codex/Neues Rezeptur-Formularium (DAC-NRF).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10553318	Barium bromide		10553-31-8	Price
AP114807-A	Neostigmine bromide		114-80-7	Price

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