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A Critical Retrospective and Prospective Review of Designs and Materials in In-Line Solid-Phase Extraction Capillary Electrophoresis

A Critical Retrospective and Prospective Review of Designs and Materials in In-Line Solid-Phase Extraction Capillary Electrophoresis

L Pont, R Pero-Gascon, E Gimenez, V Sanz-Nebot, F Benavente

Anal Chim Acta. 2019 Nov 4;1079:1-19.

PMID: 31387699

Abstract:

Several strategies have been developed to decrease the concentration limits of detection (LODs) in capillary electrophoresis (CE). Nowadays, chromatographic-based preconcentration using a microcartridge integrated in the separation capillary for in-line solid-phase extraction capillary electrophoresis (SPE-CE) is one of the best alternatives for high throughput and reproducible sample clean-up and analyte preconcentration. This review covers different designs (geometrical configurations, with frits or fritless, capillary types, compatibility with commercial instrumentation, etc.) and materials (sorbents, supports, affinity ligands, etc.) applied for almost 30 years to prepare in-line SPE-CE microcartridges (i.e. analyte concentrators), with emphasis on the conventional unidirectional configuration in capillary format. Advantages, disadvantages and future perspectives are analyzed in detail to provide the reader a wide overview about the great potential of this technique to enhance sensitivity and address trace analysis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
TIT9303	CombiCoulomat fritless			Price

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