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A Facile Method to Fabricate Thermo- And pH-sensitive Hydrogels With Good Mechanical Performance Based on Poly(ethylene Glycol) Methyl Ether Methacrylate and Acrylic Acid as a Potential Drug Carriers

A Facile Method to Fabricate Thermo- And pH-sensitive Hydrogels With Good Mechanical Performance Based on Poly(ethylene Glycol) Methyl Ether Methacrylate and Acrylic Acid as a Potential Drug Carriers

Zhen Yue, YuJu Che, Zhiwen Jin, Sisi Wang, Qinglin Ma, Qian Zhang, Yebang Tan, Fanjun Meng

J Biomater Sci Polym Ed. 2019 Oct;30(15):1375-1398.

PMID: 31220422

Abstract:

A thermo- and pH-sensitive hydrogel was prepared by a facile free aqueous radical copolymerization of PEGMA and AAc without any crosslinkers for controlled drug delivery. The successful fabrication of hydrogels was confirmed by Fourier transform infrared spectroscopy (FT-IR) and thermo gravimetric analysis (TGA) measurements. The morphological, mechanical and swelling properties of the obtained hydrogels were studied systematically. The results showed that the morphological and mechanical behaviors of the resultant hydrogels were strongly affected by the content of AAc. Moreover, the obtained hydrogels showed an excellent thermo-, pH- and salinity sensitivities. Release profiles of 5-Fu were studied at different pH (gastric pH 1.2 and intestinal pH 7.4) and temperatures (25 °C and 37 °C). The results showed that the release is very low at pH 1.2/37 °C and high at pH 7.4/25 °C. The cytotoxicity of hydrogels to cells was determined by an MTT assay. The result demonstrated that the blank hydrogels had negligible toxicity to cells, whereas the 5-Fu-loaded hydrogels remained high in cytotoxicity for LO2 and HepG-2 cells. Results of the present investigation exemplify the potential of this novel thermo- and pH-sensitive hydrogel for the controlled and targeted delivery of the anti cancer drug 5-Fu.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9004744	Poly(ethylene glycol) methyl ether		9004-74-4	Price

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