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A Hg(ClO4)2·3H2O Catalyzed Sakurai-Hosomi Allylation of Isatins and Isatin Ketoimines Using Allyltrimethylsilane

Zhong-Yan Cao, Yan Zhang, Cong-Bin Ji, Jian Zhou

Org Lett. 2011 Dec 16;13(24):6398-401.

PMID: 22111865

Abstract:

It is reported that Hg(ClO(4))(2)·3H(2)O could efficiently activate the cheap but less reactive allyltrimethylsilane for the allylation of isatins or isatin ketoimines, with catalyst loading down to 0.1 mol %. This is the first example of Sakurai-Hosomi allylation of ketoimines using allyltrimethylsilane. A rare example of chiral mercury catalysis is also reported.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP762721 Allyltrimethylsilane Allyltrimethylsilane 762-72-1 Price
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