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A Highly Efficient Biomimetic Aromatization of Hantzsch-1,4-dihydropyridines With T-Butylhydroperoxide, Catalysed by iron(III) Phthalocyanine Chloride

Mirela Filipan-Litvić, Mladen Litvić, Vladimir Vinković

Bioorg Med Chem. 2008 Oct 15;16(20):9276-82.

PMID: 18812262

Abstract:

Rapid aromatization of Hantzsch-1,4-DHPs with t-butylhydroperoxide catalysed by iron(III) phthalocyanine chloride is described. The reaction proceeds smoothly at room temperature within 1-35 min and the products of high purity were isolated in excellent yields. To explain the reactivity of this catalytical system plausible mechanism have been proposed to involve formation of high-valent oxoferryl species as in cytochrome P450 itself.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP14285564 Iron(III) phthalocyanine chloride Iron(III) phthalocyanine chloride 14285-56-4 Price
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