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A highly selective and sensitive 1,8-naphthalimide-based fluorescent sensor for Zn 2+ imaging in living cells

Daying Liu, Ye Zhao, Jun Shi, Hualing Zhu, Tingting Zhang, Pengpeng Qi, Jiatong Chen, Guangming Yang, Huarui He

Bioorg Med Chem Lett. 2019 Sep 15;29(18):2646-2649.

PMID: 31362923

Abstract:

A new 4-amino-1,8-naphthalimide-based fluorescent sensor, with iminoacetic acid and iminoethoxyacetic acid as receptor, was developed. It was applied successfully to detect Zn2+ in aqueous solution and living cells. Under physiological pH conditions, it demonstrates high selectivity and sensitivity for sensing Zn2+ with about 7-fold enhancement in aqueous solution, with a characteristic emission band of 4-amino-1,8-naphthalimide with a green color centered at 550 nm.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1742956 4-Amino-1,8-naphthalimide 4-Amino-1,8-naphthalimide 1742-95-6 Price
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