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A Literature Review of the Use of Sodium Bicarbonate for the Treatment of QRS Widening

A Literature Review of the Use of Sodium Bicarbonate for the Treatment of QRS Widening

Rebecca E Bruccoleri, Michele M Burns

J Med Toxicol. 2016 Mar;12(1):121-9.

PMID: 26159649

Abstract:

Sodium bicarbonate is a well-known antidote for tricyclic antidepressant (TCA) poisoning. It has been used for over half a century to treat toxin-induced sodium channel blockade as evidenced by QRS widening on the electrocardiogram (ECG). The purpose of this review is to describe the literature regarding electrophysiological mechanisms and clinical use of this antidote after poisoning by tricyclic antidepressants and other agents. This article will also address the literature supporting an increased serum sodium concentration, alkalemia, or the combination of both as the responsible mechanism(s) for sodium bicarbonate's antidotal properties. While sodium bicarbonate has been used as a treatment for cardiac sodium channel blockade for multiple other agents including citalopram, cocaine, flecainide, diphenhydramine, propoxyphene, and lamotrigine, it has uncertain efficacy with bupropion, propranolol, and taxine-containing plants.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP144558	Sodium bicarbonate		144-55-8	Price

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