Home
Resources
Publications
A MAGE-1 Antigenic Peptide Recognized by Human Cytolytic T Lymphocytes on HLA-A2 Tumor Cells

A MAGE-1 Antigenic Peptide Recognized by Human Cytolytic T Lymphocytes on HLA-A2 Tumor Cells

Sabrina Ottaviani, Yi Zhang, Thierry Boon, Pierre van der Bruggen

Cancer Immunol Immunother. 2005 Dec;54(12):1214-20.

PMID: 16025263

Abstract:

"Cancer-germline" genes such as those of the MAGE family are expressed in many tumors and in male germline cells, but are silent in normal tissues. They encode shared tumor-specific antigens that have been used in therapeutic vaccination trials of cancer patients. It was previously demonstrated that MAGE-1 peptide KVLEYVIKV was presented by HLA-A 0201 molecules on the surface of a human breast carcinoma cell line, but no human specific CTL had been isolated so far. Here, we have used HLA-A2/MAGE-1 fluorescent multimers to isolate from blood cells three human CTL clones that recognized the MAGE-1 peptide. These clones killed efficiently HLA-A2 tumor cells expressing MAGE-1, whether or not they were treated with IFN-gamma, suggesting that the MAGE-1 antigen is processed efficiently by both the standard proteasome and the immunoproteasome. These results indicate that the MAGE-1.A2 peptide can be used for antitumoral vaccination.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414854	MAGE-1 human			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: